Nhân sự

Hồ Việt Đức

Hồ Việt Đức

Phó Giáo sư,  Tiến sĩ

Khoa Dược Giảng viên

Lĩnh vực nghiên cứu

- Chiết xuất, phân lập, xác định cấu trúc, thử hoạt tính sinh học các hợp chất tự nhiên

- Tổng hợp, bán tổng hợp các chất có hoạt tính sinh học

- Nghiên cứu tinh dầu, hương liệu

- Hóa tính toán, mô phỏng

Đề tài NCKH chủ trì/tham gia

1. Nghiên cứu thành phần hóa học và hoạt tính gây độc tế bào của cây cơm rượu (Glycomis sp.) thuộc họ Cam (Rutaceae) ở Việt Nam- Đại học Huế - Mã số: DHH2019-04-96

2. Nghiên cứu các hợp chất có tác dụng gây độc tế bào ung thư từ cây tỏi rừng (Aspidistra sp.) ở Việt Nam- Đại học Huế - Mã số: DHH2019-04-101

3. Nghiên cứu thành phần hóa học và hoạt tính gây độc tế bào ung thư của cây bù dẻ râu (UVARIA FAUVELIANA (FIN.& GAGNEP.) – Họ NA (ANNONACEAE)- Đại học Huế - Mã số: DHH2014-04-35

4. Nghiên cứu thành phần hóa học và tác dụng ức chế Acetylcholinesterase của một số loài thuộc chi Hippeastrum Herb, ở Việt Nam- Cấp Bộ - Mã số: B2018-DHH-63

5. Nghiên cứu sàng lọc các hợp chất có hoạt tính kháng tế bào ung thư từ một số loài thực vật thuộc chi Anodendron, họ Trúc đào (Apocynaceae) ở Việt Nam- Cấp Bộ - Mã số: B2017-DHH-50

6. Nghiên cứu tác dụng ức chế phát triển tế bào ung thư từ các loài thuộc chi Hedyotis thuộc họ cà phê (Rubiaceae) có ở Việt Nam- Cấp Bộ - Mã số: B2015-DHH-126

7. Đánh giá hoạt tính kháng ung thư và kháng viêm của các hợp chất phân lập từ các loài thuộc chi Chisocheton ở Việt Nam- Nafosted - Mã số: 104-01-2017.09

Công bố quốc tế

1. Hien Bich Thi Le, Duc Viet Ho, Hien Minh Nguyen, Van Anh Thi Tran, Hoai Thi Nguyen. 2023. Aspidiatas C and D, two new spirostanol saponins fromAspidistra triradiataand their cytotoxic activities. Natural Product Research: (): 1-9. doi: 10.1080/14786419.2023.2204432

2. Tan Khanh Nguyen, Yen Thi Le, Duc Viet Ho, Hoai Thi Nguyen, Linh Thuy Thi Tran. 2023. Xanthine Oxidase Inhibitory Activity of Fatty Acids From Hedyotis pilulifera: In Vitro and In Silico Studies. Natural Product Communications: 18, 8. doi: 10.1177/1934578x231192161

3. Tan Khanh Nguyen, Linh Thuy Thi Tran, Trung Truong Tan, Phu Tran Vinh Pham, Linh Thuy Khanh Nguyen, Hoai Thi Nguyen, Duc Viet Ho, Manh Hung Tran. 2023. Isolation, structural elucidation, and cytotoxic activity investigation of novel styryl-lactone derivatives fromGoniothalamus elegans:in vitroandin silicostudies. RSC Advances: 13, 2617587-17594. doi: 10.1039/d3ra02646a

4. Tan Khanh Nguyen, Linh Thuy Thi Tran, Duc Ho Viet, Pham Hong Thai, Tran Phuong Ha, Pham Viet Ty, Le Phu Duc, Dat Ton That Huu, Le Canh Viet Cuong. 1970. Xanthine oxidase, α-glucosidase and α-amylase inhibitory activities of the essential oil from Piper lolot: In vitro and in silico studies. Heliyon: 9, 8e19148. doi: 10.1016/j.heliyon.2023.e19148

5. Linh Thuy Khanh Nguyen, Tuan Quoc Doan, Phu Quynh Dinh Nguyen, Chau Bao Hoai Nguyen, Linh Thuy Thi Tran, Thi Van Anh Tran, Hoai Thi Nguyen, Duc Viet Ho. 2023. Phytochemical Composition and Bioactivities of Essential Oils from Rhizomes of Homalomena pendula and Homalomena cochinchinensis. Natural Product Communications: 18, 51934578X2311752. doi: 10.1177/1934578x231175263

6. Linh Thuy Khanh Nguyen, Phu Quynh Dinh Nguyen, Nghia Ai Thi Doan, Chau Bao Hoai Nguyen, Tuan Quoc Doan, Linh Thuy Thi Tran, Hoai Thi Nguyen, Duc Viet Ho. 2023. Volatile Components and Biological Activities of n-Hexane Extract From Rhizomes of Homalomena cochinchinensis. Natural Product Communications: 18, 41934578X2311684. doi: 10.1177/1934578x231168481

7. Tuan Quoc Doan, Dien Dinh, Thang Nam Tran, Phu Quynh Dinh Nguyen, Chau Bao Hoai Nguyen, Nhan Trong Le, Hung Quoc Vo, Duc Viet Ho, Anh Le Tuan, Hoai Thi Nguyen, Isiaka A. Ogunwande. 2023. Chemical composition and acetylcholinesterase inhibitory activity of essential oil from the leaves of Mitrephora poilanei Weeras. & R.M.K. Saunders. Natural Product Research: (): 1-5. doi: 10.1080/14786419.2023.2227989

8. Ty Viet Pham, Duc Viet Ho, Anh Tuan Le, Y Duy Ngo, Nhan Thanh Thi Dang, Thang Quoc Le, Bao Chi Nguyen. 2023. Chemical composition and biological activities of essential oil from Grewia bulot leaves. Natural Product Research: (): 1-7. doi: 10.1080/14786419.2023.2275739

9. Nguyen Huu Quan, Pho Thi Thuy Hang, Nguyen Thi Thu Nga, Ho Viet Duc, Vu Thi Hue, Sy Danh Thuong, Le Nguyen Thanh, Chu Hoang Mau. 2023. Chemical constituents and biological activities of the leaves of Adinandra megaphylla. Phytochemistry Letters: 56 (): 19-23. doi: 10.1016/j.phytol.2023.06.002

10. Hanh Nhu Thi Hoang, Hung Quoc Vo, Linh Thuy Thi Tran, Hoai Thi Nguyen, Duc Viet Ho. 2023. Conarubins A–D: Four Monoterpene–Chalcone Conjugates from Conamomum rubidum and Their Anti-inflammatory and Cytotoxic Activities. The Journal of Organic Chemistry: 88 (21): 15318-15325. doi: 10.1021/acs.joc.3c01825

11. Duc V. Ho, Hanh N. T. Hoang, Nguyen H. Nguyen, Hang B. Do, Hung Q. Vo, Anh T. Le, Thang Q. Le, Ty V. Pham. 2023. GC-MS Characterization, in Vitro Antioxidant and Anti-Inflammatory Activities of Essential oil from the Leaves of Litsea balansae Lecomte. Natural Product Communications: 18 (11): . doi: 10.1177/1934578x231214159

12. Nhan Trong Le, Trieu Phat Dac Nguyen, Duc Viet Ho, Huong Thanh Phung, Hoai Thi Nguyen. 2023. Green solvents-based rutin extraction from Sophora japonica L.. Journal of Applied Research on Medicinal and Aromatic Plants: 36 (): 100508. doi: 10.1016/j.jarmap.2023.100508

13. Linh Thuy Khanh Nguyen, Hung Quoc Vo, Hanh Nhu Thi Hoang, Thi Van Anh Tran, Hien Minh Nguyen, Ty Viet Pham, Hang Phuong Thi Ngo, Thanh Pham, Duc Viet Ho. 2023. Structure revision and absolute configuration of 5,7-diepi-2α-hydroxyoplopanone and anti-osteoporotic activities of sesquiterpenoids from the rhizomes of Homalomena pendula. Natural Product Research: (): 1-10. doi: 10.1080/14786419.2023.2180505

14. Ty Viet Pham, Duc Viet Ho, Anh Tuan Le, Y Duy Ngo, Nhan Thi Thanh Dang, Thang Quoc Le, Bao Chi Nguyen. 2023. Volatile Organic Compounds and Antioxidant, Cytotoxic Activities of Extracts from the Leaves of Grewia bulot. Indonesian Journal of Chemistry: 23 (5): 1394. doi: 10.22146/ijc.84619

15. Diep Thi Lan Phuong, Nguyen Thanh Cong, Nguyen Van Phuong, Nguyen Thi Hue, Nguyen Quoc Vuong, Nguyen Thi Phuong Lien, Duc Viet Ho, Nguyen Le Tuan, Nguyen Thị Nghia, Vo Thi Thanh Tuyen, Nguyen Thu Hang, Le Thanh. 2023. Chemical Constituents, Cytotoxicity, and Molecular Docking Studies of Tetragonula iridipennis Propolis. Natural Product Communications: 18, 12. doi: 10.1177/1934578x231219088

16. Hien Bich Thi Le, Van Anh Thi Tran, Hien Minh Nguyen, Linh Thuy Khanh Nguyen, Duc Viet Ho, Hoai Thi Nguyen. 2023. Aspidiata E, a New Spirostanol Saponin From Aspidistra triradiata and its Cytotoxic Activity. Natural Product Communications: 18 (6): 1934578X2311794. doi: 10.1177/1934578x231179412

17. Dat Ton That Huu, Ha Tran Phuong, Phan Thi Diem Tran, Bakeo Souvannalath, Hieu Le Trung, Duc Viet Ho, Cuong Le Canh Viet. 2022. Secondary Metabolites From the Grasshopper-Derived Entomopathogenic Fungus Aspergillus Tamarii NL3 and Their Biological Activities. Natural Product Communications: 17 (12): 1934578X2211415. doi: 10.1177/1934578x221141548

18. Nguyen LTK, Hoang HNT, Tran TVA, Nguyen HT, Ho DV. Homalolides C-D, two new sesquiterpenoids from the rhizomes of Homalomena pendula. Natural Product Research. 2022:1-8. doi: 10.1080/14786419.2022.2103557

19. Nguyen LTK, Hoang HNT, Do TT, Tran TVA, Nguyen HT, Ho DV. Sesquiterpenoids from the rhizomes of Homalomena pendula and their anti-inflammatory activities. Natural Product Research. 2022:1-9. doi: 10.1080/14786419.2022.2056182

20. Bich Thi Le H, Viet Ho D, Minh Nguyen H, Tuan Le A, Tran TVA, Nguyen HT. A new spirostanol steroid and a new spirostanol steroidal saponin from Aspidistra triradiata and their cytotoxic activities. Natural Product Research. 2022:1-10. doi: 10.1080/14786419.2022.2095635

21. Nguyen LTK, Nguyen PQD, Nguyen CBH, et al. Sesquiterpenoids from the rhizomes of Homalomena pendula (Blume) Bakhf showing acetylcholinesterase inhibitory activity: in vitro and in silico studies. Chemical Papers. 2022. doi: 10.1007/s11696-022-02573-7

22. Tran LTT, Le TN, Ho DV, et al. Virtual Screening and in Vitro Evaluation to Identify a Potential Xanthine Oxidase Inhibitor Isolated from Vietnamese Uvaria cordata. Natural Product Communications. 2022;17(2):1934578X2210803. doi: 10.1177/1934578X221080339

23. Tran LTT, Dang NYT, Nguyen Le NT, et al. In Silico and in Vitro Evaluation of Alkaloids from Goniothalamus elegans Ast for Breast Cancer Treatment. Natural Product Communications. 2022;17(3):1934578X2210881. doi: 10.1177/1934578X221088110

24. Nguyen TK, Tran TH, Nguyen K, Ho DV, Nguyen HT, Tran LTT. Deep Learning Model to Identify Potential Acetylcholinesterase Inhibitors: A Case Study of Isolated Compounds From Pongamia pinnata (L) Pierre. Natural Product Communications. 2022;17(7):1934578X2211173. doi: 10.1177/1934578X221117310

25. Tuan DQ, Dinh D, Tran TN, et al. Chemical Composition of Essential Oil from the Zingiber monophyllum (Zingiberaceae) from Vietnam. Journal of Essential Oil Bearing Plants. 2022;25(5):987-993. doi: 10.1080/0972060X.2022.2132835

26. Witayateeraporn W, Nguyen HM, Ho DV, et al. Aspiletrein A Induces Apoptosis Cell Death via Increasing Reactive Oxygen Species Generation and AMPK Activation in Non-Small-Cell Lung Cancer Cells. International Journal of Molecular Sciences. 2022;23(16):9258. doi: 10.3390/ijms23169258

27. Viet Cuong LC, Nhi NPK, Ha TP, et al. A new steroidal saponin from the aerial parts of Solanum torvum. Natural Product Research. 2021:1-6. doi: 10.1080/14786419.2021.1908282

28. Ho DV, Nguyen HT, Vu T, Pham TV, Nguyen HM. Antioxidant Activity of a New Xanthone Derivative from Aspidistra Letreae : In Vitro and In Silico Studies. Chemistry & Biodiversity. 2021;18(4). doi: 10.1002/cbdv.202001008

29. Oanh VTK, Ha NTT, Duc HV, Thuc DN, Hang NTM, Thanh LN. New triterpene and nor-diterpene derivatives from the leaves of Adinandra poilanei. Phytochemistry Letters. 2021;46:110-113. doi: 10.1016/j.phytol.2021.10.003

30. Nguyen KV, Nguyen TOT, Ho DV, Heinämäki J, Raal A, Nguyen HT. In Vitro Acetylcholinesterase Inhibitory and Antioxidant Activity of Alphonsea tonkinensis ADC. Natural Product Communications. 2021;16(9):1934578X2110421. doi: 10.1177/1934578x211042134

31. Tuan DQ, Dien D, Pham TV, et al. Chemical Composition of Essential Oil from the Rhizomes and Leaves of Newmania sontraensis HÐTrân, Luu & Škornick (Zingiberaceae) from Vietnam. Journal of Essential Oil Bearing Plants. 2021;24(6):1260-1268. doi: 10.1080/0972060X.2022.2026253

32. Nguyen HM, Nguyen HT, Seephan S, et al. Antitumor activities of Aspiletrein A, a steroidal saponin from Aspidistra letreae, on non-small cell lung cancer cells. BMC Complementary Medicine and Therapies. 2021;21(1). doi: 10.1186/s12906-021-03262-w

33. Pham TV, Le TQ, Le AT, Vo HQ, Ho DV. Phytochemical Constituents of Annona reticulata and their Cytotoxic Activity. Letters in Organic Chemistry. 2020;17(3):206-210. doi: 10.2174/1570178616666190724123004

34. Trong Le N, Viet Ho D, Quoc Doan T, et al. Biological Activities of Essential Oils from Leaves of Paramignya trimera (Oliv) Guillaum and Limnocitrus littoralis (Miq) Swingle. Antibiotics. 2020;9(4):207. doi: 10.3390/antibiotics9040207

35. Nguyen KV, Ho DV, Nguyen HM, et al. chiro-Inositol Derivatives from Chisocheton paniculatus Showing Inhibition of Nitric Oxide Production. Journal of Natural Products. 2020;83(4):1201-1206. doi: 10.1021/acs.jnatprod.9b01239

36. Trong Le N, Viet Ho D, Quoc Doan T, et al. In Vitro Antimicrobial Activity of Essential Oil Extracted from Leaves of Leoheo domatiophorus Chaowasku, DT Ngo and HT Le in Vietnam. Plants. 2020;9(4):453. doi: 10.3390/plants9040453

37. Ho DV, Hoang HNT, Vo HQ, et al. Three new steroidal saponins from Aspidistra letreae plants and their cytotoxic activities. Journal of Natural Medicines. 2020;74(3):591-598. doi: 10.1007/s11418-020-01395-9

38. Hoang THX, Ho DV, Van Phan K, Le QV, Raal A, Nguyen HT. Effects of Hippeastrum reticulatum on memory, spatial learning and object recognition in a scopolamine-induced animal model of Alzheimer’s disease. Pharmaceutical Biology. 2020;58(1):1107-1113. doi: 10.1080/13880209.2020.1841810

39. Nguyen KV, Ho DV, Le NT, et al. Flavonoids and alkaloids from the rhizomes of Zephyranthes ajax Hort and their cytotoxicity. Scientific Reports. 2020;10(1). doi: 10.1038/s41598-020-78785-2

40. Minh Nguyen H, Truong Nguyen H, Win N, et al. Antimelanogenic Activity of Ocotillol‐Type Saponins from Panax vietnamensis. Chemistry & Biodiversity. 2020;17(5). doi: 10.1002/cbdv.202000037

41. Le NT, Donadu MG, Ho DV, et al. Biological activities of essential oil extracted from leaves of Atalantia sessiflora Guillauminin Vietnam. The Journal of Infection in Developing Countries. 2020;14(09):1054-1064. doi: 10.3855/jidc.12469

42. Pham TV, Bach HKT, Ho DV, Nguyen BC. Chemical constituents from the Knema globularia fruits and their in vitro cytotoxicity. Natural Product Research. 2020;36(1):256-262. doi: 10.1080/14786419.2020.1777416

43. . In Vitro Cytotoxic Activity of Constituents of the Aerial Parts of Glycosmis parviflora. Tropical Journal of Natural Product Research. 2020;4(10):703-707. doi: 10.26538/tjnpr/v4i10.8

44. Yen PH, Cuc NT, Huong PTT, et al. Araliachinoside A: A New Triterpene Glycoside From Aralia chinensis Leaves. Natural Product Communications. 2020;15(9):1934578X2095275. doi: 10.1177/1934578X20952756

45. Tran L, Ho D, Le D, Nguyen H, Raal A. The effect of Pogostemon auricularius fractions and its compounds on some proinflammatory and anti-inflammatory molecules in LPS-stimulated RAW 2647 macrophages. American Journal of Physiology, Biochemistry and Pharmacology. 2020;10(1):1. doi: 10.5455/ajpbp.20190920041706

46. Viet Nguyen K, Laidmäe I, Kogermann K, et al. Preformulation Study of Electrospun Haemanthamine-Loaded Amphiphilic Nanofibers Intended for a Solid Template for Self-Assembled Liposomes. Pharmaceutics. 2019;11(10):499. doi: 10.3390/pharmaceutics11100499

47. Nguyen HT, Tran LTT, Ho DV, Phan KV, Raal A, Morita H. Three new inositol derivatives from Chisocheton paniculatus. Tetrahedron Letters. 2019;60(28):1841-1844. doi: 10.1016/j.tetlet.2019.06.015

48. Doan TQ, Ho DV, Trong Le N, et al. Chemical composition and anti-inflammatory activity of the essential oil from the leaves of Limnocitrus littoralis (Miq) Swingle from Vietnam. Natural Product Research. 2019;35(9):1550-1554. doi: 10.1080/14786419.2019.1652286

49. Ho DV, Tran LTT, Le DV, et al. A New Triterpene and a New Phloroglucinol Derivative from the Aerial Parts of Pogostemon auricularius. Chemistry of Natural Compounds. 2019;55(5):890-894. doi: 10.1007/s10600-019-02839-9

50. Tuan DQ, Duc HV, Nhan LT, Anh LT, Hoai NT, Raal A. Constituents of Essential Oils from the Leaves of Paramignya trimera (Oliv) Guillaum from Vietnam. Journal of Essential Oil Bearing Plants. 2019;22(2):391-395. doi: 10.1080/0972060X.2019.1582362

51. Tran LTT, Ho DV, Le DV, Van Phan K, Nguyen HT, Raal A. Apoptosis-Inducing Effect of Pogostemin A Isolated from the Aerial Parts ofPogostemon auriculariusAgainst the Human Lung Cancer Cells. Journal of Biologically Active Products from Nature. 2019;9(5):320-327. doi: 10.1080/22311866.2019.1687334

52. Nguyen HT, Doan HT, Ho DV, Pham KT, Raal A, Morita H. Huperphlegmines A and B, two novel Lycopodium alkaloids with an unprecedented skeleton from Huperzia phlegmaria , and their acetylcholinesterase inhibitory activities. Fitoterapia. 2018;129:267-271. doi: 10.1016/j.fitote.2018.07.016

53. Nguyen HT, Tran LTT, Ho DV, Le DV, Raal A, Morita H. Pogostemins A-C, three new cytotoxic meroterpenoids from Pogostemon auricularius. Fitoterapia. 2018;130:100-104. doi: 10.1016/j.fitote.2018.08.015

54. Tran LTT, Ho DV, Le DV, Hung TM, Nguyen HT, Raal A. Three new phloroglucinol derivatives from the aerial parts of Pogostemon auricularius and their cytotoxic activity. Phytochemistry Letters. 2018;28:88-92. doi: 10.1016/j.phytol.2018.09.016

55. Nguyen HT, Ho DV, Nguyen PDQ, Vo HQ, Do TT, Raal A. Cytotoxic Evaluation of Compounds Isolated from the Aerial Parts of Hedyotis pilulifera and Methanol Extract of Inonotus obliquus. Natural Product Communications. 2018;13(8):1934578X1801300. doi: 10.1177/1934578X1801300805

56. Doan TH, Ho VD, Le TBH, et al. Two new abietane diterpenes huperphlegmarins A and B from Huperzia phlegmaria. Natural Product Research. 2018;33(14):2051-2059. doi: 10.1080/14786419.2018.1484462

57. Ho DV, Vo HQ, Nguyen TH, Do TT, Nguyen HT. A New Cytotoxic Tetrahydroxanthene-1,3(2H)-dione Derivative from Uvaria cordata and Structure Revision of Valderramenol A. Natural Product Communications. 2018;13(5):1934578X1801300. doi: 10.1177/1934578X1801300517

58. Hoai NT, Duc HV, Raal A, Morita H. A New Limonoid from Chisocheton paniculatus Fruit Collected in Vietnam and Its NO Production Inhibitory Activity. Natural Product Communications. 2018;13(10):1934578X1801301. doi: 10.1177/1934578X1801301005

59. Nguyen HT, Ho DV, Vo HQ, et al. Antibacterial activities of chemical constituents from the aerial parts of Hedyotis pilulifera. Pharmaceutical Biology. 2017;55(1):787-791. doi: 10.1080/13880209.2017.1279673

60. Ho VD, Hoang TNH, Vo QH, et al. Cycloartane-type triterpene glycosides anopanins A-C with monoacyldigalactosylglycerols from Anodendron paniculatum. Phytochemistry. 2017;144:113-118. doi: 10.1016/j.phytochem.2017.09.004

61. Sak K, Nguyen TH, Ho VD, Do TT, Raal A. Cytotoxic effect of chamomile (Matricaria recutita) and marigold (Calendula officinalis) extracts on human melanoma SK-MEL-2 and epidermoid carcinoma KB cells. Cogent Medicine. 2017;4(1):1333218. doi: 10.1080/2331205X.2017.1333218

62. Ho DV, Kodama T, Le HTB, et al. A new polyoxygenated cyclohexene and a new megastigmane glycoside from Uvaria grandiflora. Bioorganic & Medicinal Chemistry Letters. 2015;25(16):3246-3250. doi: 10.1016/j.bmcl.2015.05.066

63. Raal A, Hoai N, Duc H, Thao D, Orav A. Selectivity of Pinus sylvestris extract and essential oil to estrogen-insensitive breast cancer cells Pinus sylvestris against cancer cells. Pharmacognosy Magazine. 2015;11(44):290. doi: 10.4103/0973-1296.166052

64. Nhiem NX, Van Kiem P, Van Minh C, et al. Anti-influenza Sesquiterpene from the Roots of Reynoutria japonica. Natural Product Communications. 2014;9(3):1934578X1400900. doi: 10.1177/1934578X1400900308

65. Cuong NM, Khanh PN, Duc HV, et al. Vasorelaxing Activity of Two Coumarins from <i>Murraya paniculata</i> Leaves. Biological and Pharmaceutical Bulletin. 2014;37(4):694-697. doi: 10.1248/bpb.b13-00905

66. Cuong NM, Khanh PN, Huyen PT, et al. Vascular L-Type Ca2+Channel Blocking Activity of Sulfur-Containing Indole Alkaloids fromGlycosmis petelotii. Journal of Natural Products. 2014;77(7):1586-1593. doi: 10.1021/np500076v

67. Tung MHT. Cytotoxic Compounds from Brucea mollis. Scientia Pharmaceutica. 2013;81(3):819-831. doi: 10.3797/scipharm.1206-02

68. Nhan Trong Le, Trieu Phat Dac Nguyen, Duc Viet Ho, Huong Thanh Phung, Hoai Thi Nguyen. 1970. A green method to extract rutin from Sophora japonica L.. MethodsX: 11, 102479. doi: 10.1016/j.mex.2023.102479